Nearly twothirds of these patients are diagnosed at. Despite treatmentrelated advances, the prognosis of lung cancer remains poor with a 5year survival rate of 4% in distantstage disease. Regardless of the cell type, the icd 9 cm code for primary malignant neoplasm of the lung is 162. Introduction concurrent chemoradiotherapy ccrt was the standard of care for patients with unresectable stage iii non small cell lung cancer nsclc prior to the pacific trial, however, patients also received single modality therapy. The california cancer registry was merged with the patient discharge data set to determine the incidence of vte among lung cancer cases diagnosed between 1993 and 1999. American journal of respiratory and critical care medicine. Nov 28, 2019 because bevacizumab is used for non smallcell lung cancers, patients with smallcell or neuroendocrine lung cancer according to icdo3 histology codes were excluded from this analysis exclusion. Comparison of demographics, treatment patterns, health care. Previous studies have indicated a high accuracy of the icd9cm diagnoses in the nhird 20, 21. Bevacizumab for the treatment of nonsmall cell lung. Accuracy of lung cancer icd9cm codes in umbria, napoli 3.
Predictors of chemoradiotherapy versus single modality. Usingdatafromthree populationbasedregistries inthenational cancer institutes surveillance, epidemiology and end results seer program, surgical treatment amongblack. However, to our knowledge, no modern trials have compared the most common treatments for nsclc. Administrative healthcare databases are useful tools to study healthcare outcomes and to monitor the health status of a population find, read and cite all the research. The cancer types were identified using icd9cm codes see table 1b. Lifetime occurrence of brain metastases arising from lung. The radiologist also notes a secondary diagnosis of coronary arteriosclerosis, there is no mention of prior bypass. Lung cancer is the most common cause of cancer death worldwide, 1 and most patients have advancedstage disease at diagnosis.
Procedural aggressiveness in veterans with advanced non. The gems are the raw material from which providers, health information vendors and payers can. Introduction in patients with advanced stage iiibiv non smallcell lung cancer nsclc, platinumbased chemotherapy regimens have provided improvement in shortterm survival, symptom control, and quality of life. Enhanced yap expression leads to egfr tki resistance in. Nearly twothirds of these patients are diagnosed at age 65 years or older, with an estimated median age at diagnosis of 70 years. With an estimated 222,500 newly diagnosed cases of lung cancer and 155,870 deaths expected in 2017, lung cancer represents the second most common cancer and the leading cause of cancer death in the united states. Inhaled corticosteroids may prevent lung cancer in asthma.
Treatment of nonsmall cell lung cancer jama network. This included 19,702 stage i, 3,753 stage ii, 10,429 stage iiia, 22,285 stage iiib, and 45,675 stage iv nsclc patients. We identified medicare beneficiaries with primary non smallcell lung cancer nsclc, who underwent lobectomy or slr between 1 october 2007 and 30 june 2012, from the linked database. Non small cell lung cancer, negative for epidermal growth factor receptor expression. Patients with stage iii nsclc have a 5year survival rate ranging from %36% 2, 46. In this study, we sought to determine the accuracy with which the international classification of diseases, 9th edition, clinical modification icd9cm diagnosis code for secondary neoplasm of brain and spinal cord in health insurance claims measures clinically evident central nervous system cns metastases in patients with non small cell lung cancer nsclc. Coders routinely download the most uptodate encoder software. The greatest sbm ip among patients with lung cancer was. Marciniak, phd,2 douglas faries, phd,2 michael stokes, mph,1,4 don buesching, phd,2 craig earle, md, msc,3 joseph treat, md,2 steve babineaux, ms,2 nathalie morissette, msc,1 david thompson, phd1 1i3 innovus, medford, ma, usa. Icd9cm to icd10cm based on fy2014 icd9cm codes reportable neoplasms category and subcategory codes are shaded in grey and marked with an cells shaded in pink and marked with an indicate the preferred code when a single code maps to multiple codes see introduction reportable list. Validity of icd9cm codes for breast, lung and colorectal cancers in. Is incentive spirometry beneficial for patients with lung.
Non smallcell lung cancer nsclcb comprises 75 to 80 percent of all lung cancers, and about 30 percent of patients are candidates for curative surgical resection 1, 2. Non small cell lung cancer nsclc accounts for 80% to 85% of all lung cancer 222,500 new cases per year in the united states, and the predominant proportion of the patients 80% are ultimately diagnosed as stage iv disease. Tables 1 and 2 summarize patient characteristics and overall 5year survival across cancers. Overview of tumors, cancer and oncology c00d48, 140239.
Jun 27, 2009 in this study, we sought to determine the accuracy with which the international classification of diseases, 9th edition, clinical modification icd9cm diagnosis code for secondary neoplasm of brain and spinal cord in health insurance claims measures clinically evident central nervous system cns metastases in patients with non small cell lung cancer nsclc. Coding and billing for diagnosis and treatment of prostate cancer. The subjects were persons with a form of lung cancer for which surgical resection has been shown to confer a definitive benefit stage i or stage ii non smallcell lung cancer. Lung cancer is the leading cause of mortality in all patients with cancer, accounting for 14% of newly diagnosed cancer cases and 26% to 28% of all cancer deaths in the united states. Similar longterm survival of elderly patients with nonsmall cell lung cancer treated with lobectomy or wedge resection within the surveillance, epidemiology, and end results database. Short version of 20 icd9cm casefinding list for reportable tumors codes and explanations. We identified 66,297 patients with a new diagnosis of lung cancer icd9cm code 162 in the lhidcip from 2000 to 2008. Validity of icd9cm codes for breast, lung and colorectal. Surgery of nsclcs includes wedge resection, sleeve lobectomy, lobectomy, and pneumonectomy if there is no. Lung cancer is one of the leading causes of cancerrelated deaths in the world. Non small cell lung cancers nsclcs are the most common types of lung cancers and have diverse pathological characteristics. Costs of firstline doublet chemotherapy and lifetime. Using data from the surveillance, epidemiology, and end results registry linked to medicare claims, we identified 750 patients with diabetes 6580 years of age diagnosed.
The influence of hospital volume on survival after resection. When possible, they are primarily treated by surgical resection with curative intent, although chemotherapy has been used. This is a shortened version of the second chapter of the icd9. Metformin prolongs survival in type 2 diabetes lung cancer. Wholebrain radiation therapy wbrt with or without surgical resection has. Comorbidity romanocharlson index was calculated using administrative data codes. Even with treatment, the prognosis for these patients remains poor with a median survival of 7 months. For lung cancer, we will consider the icd9cm codes 162. Icd9cm codes in identifying subjects with lung cancer. Survival from lung cancer is highly associated with lung resection surgery. This type of lung cancer is more common than small cell.
Methods this retrospective study included stage iii nsclc patients aged. Disparities in systemic treatment use in advancedstage non. As a class, nsclcs are relatively insensitive to chemotherapy, compared to small cell carcinoma. These years were chosen because many of the detailed icd9cm codes. The masstumor is specified in the report as being in the upper lobe. The most common form of the disease is non small cell lung cancer nsclc, which accounts for approximately 75%87% of all cases 2, 3. Even with treatment, the prognosis for these patients remains poor, with a median survival of 7 months, although certain subgroups experience a median survival up to 15 months. Non small cell lung cancers include squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Accuracy of lung cancer icd9cm codes in umbria, napoli 3 sud and friuli venezia giulia administrative healthcare databases. Importance the incidence of earlystage nonsmall cell lung cancer nsclc among the elderly is expected to rise dramatically owing to demographic trends and increased computed tomographic screening. Nsclc patients present with stage iii disease in approximately one third of all cases, and of those cases, only a minority are considered surgically resectable 25. The study population comprised 3,672,561 patients of whom 37. Safety outcomes in advanced nonsmallcell lung cancer.
The role that health insurance plays in receipt of systemic treatments is unclear. Combined small cell lung carcinoma or csclc, and rarely rendered as smallcell lung carcinoma is a form of multiphasic lung cancer that is diagnosed by a pathologist when a malignant tumor arising from transformed cells originating in lung tissue contains a component of small cell lung carcinoma sclc admixed with one or more components of non small cell lung carcinoma nsclc. Costs of firstline doublet chemotherapy and lifetime medical. At diagnosis, 70 % of patients have advanced or metastatic disease, and systemic chemotherapy is the main treatment modality employed to prolong survival 2. All cases of localized non small cell lung cancer reported to our state cancer registry between 1996 and 2002 were identified and linked to the inpatientoutpatient surgery files and 2000 census. Lung cancer harbored the highest incidence of brain metastasis in relation to all malignancies. Adapting a clinical comorbidity index for use with icd9cm administrative databases. These years were chosen because many of the detailed icd9cm codes became available on 1 october 2007. Downloadable files of diagnosis and procedure codes and their full and abbreviated titles are available in the downloads and related links.
To identify nsclc from the overall lung cancer sample, patients receiving chemotherapy regimens characteristic of treatment for small cell lung cancer sclc were excluded. For noninvasive breast cancer, we will consider the icd9cm code. Underuse of surgical resection for localized, nonsmall cell. Further studies are urgently needed to identify the patient, physician, and health systemrelated factors underlying these observations and optimize resection rates for non small cell lung cancer. Disparities in surgical treatmentof earlystage nonsmall. Approximately 14% of new diagnoses are classified as having small cell lung cancer sclc, while the remaining 85% of cases are non small cell lung cancer nsclc. Firstline treatment with bevacizumab and platinum doublet. Non small cell lung cancer nsclc accounts for 80%85% of all newly diagnosed lung cancer cases. Between 50 and 80% of patients with lung cancer have copd, and recent estimates of lung cancer risk in copd have been as high as 167 per 10,000 personyears, substantially higher than the overall risk of 6. Underuse of surgical resection for localized, non small cell lung cancer is a persistent problem, particularly among african americans. Carboplatin and paclitaxel with vs without bevacizumab in. Utility of administrative claims data for the study of brain. A total of 222,500 new cases of lung cancer and 155,870 lung cancer deaths were estimated for 2017. Sublobar resection for nodenegative lung cancer 25 cm in.
Data were obtained on 101,844 incident non small cell lung cancer nsclc cases in the ccr during the period from 1989 to 2003 with tnm staging data and complete followup data available. Non hodgkins lymphoma small cleaved cell, follicular non hodgkins lymphoma mixed small cleaved and large cell, follicular 202. Pdf accuracy of lung cancer icd9cm codes in umbria. Until the recent emergence of immune checkpoint inhibitors icis, platinumbased chemotherapy has been the gold standard for the firstline. The diagnostic accuracy of lung cancer was confirmed by both specific icd9cm codes and inclusion in the registry for catastrophic illness patient database. Nov, 2014 approximately 14% of new diagnoses are classified as having small cell lung cancer sclc, while the remaining 85% of cases are non small cell lung cancer nsclc. Malignant neoplasm of bronchus and lung, unspecified. The patient selection process necessarily excluded patients who had a wedge resection by either method during this time period but in whom histology was benign. Non small cell lung cancer nsclc is the leading cause of cancerrelated deaths in the usa, accounting for25 % of all cancerrelated deaths in both men and women 1.
Both volumes can be downloaded for free from the website of the world health. In the neoplasm table, lungupper lobeprimary is 162. Icd9cm diagnosis and procedure codes for identifying the wedge resection procedures, cancer diagnoses, comorbid conditions, and all adverse events are listed in eappendixes 1 through 4. Pneumoconioses and other lung diseases due to external agents 500508. Diagnosis in the early stages provides the greatest chance for survival. To code a diagnosis of this type, you must use one of the three child codes of c34. The incidence of venous thromboembolism among patients. Non smallcell lung carcinoma nsclc is any type of epithelial lung cancer other than small cell lung carcinoma sclc. Use of stereotactic radiosurgery for brain metastases from.
Disparities in systemic treatment use in advancedstage. Natural history of stage i nonsmall cell lung cancer chest. Chronic obstructive pulmonary disease copd and lung cancer cause significant morbidity and mortality. Because bevacizumab is used for non smallcell lung cancers, patients with smallcell or neuroendocrine lung cancer according to icdo3 histology codes were. Genderbased impact of epidermal growth factor receptor. Objective to determine clinical characteristics and survival outcomes. Equivalence map definitions the icd9 and icd10 gems are used to facilitate linking between the diagnosis codes in icd 9 cm and the new icd10cm code set. Comparison of demographics, treatment patterns, health. Approximately 40 % of all patients with non small cell lung cancer nsclc will develop brain metastasis during the course of their disease. We followed all patients until the first diagnosis of lc, withdrawal from the national health insurance program, or. A diagnostic accuracy study article pdf available in bmj open 85. Plus supplementary lists of codes that are not reportable or neoplasmrelated. Non small cell lung cancer nsclc is the most common type of lung cancer, accounting for approximately 80%85% of cases. Lung cancer remains the second most commonly diagnosed cancer in the united states us, with approximately 225,000 new cases and 160,000 deaths expected in 2014.
For claims with a date of service on or after october 1, 2015, use an equivalent icd10cm code or codes. For earlystage nsclc, we measured receipt of surgical lung resection in the period 3 months before through 5 months after the lung cancer diagnosis month, as indicated in the seer registry data codes 1070, 90 andor the presence of claims with relevant icd9 procedure codes 32. Time to initial cancer treatment in the united states and. The latter index focuses on chronic illnesses such as congestive heart failure icd9cm codes 402 through 404, liver disease icd9cm code 572, and chronic obstructive pulmonary disease icd9. To compare overall survival of patients with diabetes with stage iv non small cell lung cancer nsclc taking metformin versus those not on metformin. Racial differences in the treatment of earlystage lung cancer. Realworld treatment patterns, overall survival, and. Patients with a history of tobacco use icd9cm codes v15. Utility of administrative claims data for the study of.
Procedural aggressiveness in veterans with advanced nonsmall. Underuse of surgical resection for localized, nonsmall. Bevacizumab for the treatment of nonsmall cell lung cancer. Management of advancedstage nonsmall cell lung cancer nsclc has changed significantly over the past two decades with the development of numerous systemic treatments, including targeted therapies. This study identified predictors of therapy and differences in overall survival os. Icd9 code 185 and icd10 code c61 are the diagnostic codes used for. Eatonlambert syndrome due to small cell carcinoma of lung.
However, a high proportion of advancedstage patients are untreated. Increased survival with the combination of stereotactic. Approximately 20% of patients with non small cell lung cancer nsclc will develop brain metastases in their lifetime. Costs of firstline doublet chemotherapy and lifetime medical care in advanced non smallcell lung cancer in the united states kathleen lang, phd,1,5 martin d. Budget impact analysis of afatinib for firstline treatment. The influence of hospital volume on survival after.
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